2-chloro-5,6,7,8-tetrahydro-[1,6]naphthyridine

2-chloro-5,6,7,8-tetrahydro-[1,6]naphthyridine - Names and Identifiers

Name	2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine
Synonyms	2-Chloro-5,6,7,8-tetrahydro-[1,6]naphthyridin 1,6-phthyridine, 2-chloro-5,6,7,8-tetrahydro- 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine 2-chloro-5,6,7,8-tetrahydro-[1,6]naphthyridine 1,6-Naphthyridine, 2-chloro-5,6,7,8-tetrahydro- 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride
CAS	210539-05-2
InChI	InChI=1/C8H9ClN2/c9-11-4-2-7-5-10-3-1-8(7)6-11/h1,3,5H,2,4,6H2

2-chloro-5,6,7,8-tetrahydro-[1,6]naphthyridine - Physico-chemical Properties

Molecular Formula	C8H9ClN2
Molar Mass	168.62
Density	1.226±0.06 g/cm3(Predicted)
Boling Point	284.8±40.0 °C(Predicted)
pKa	7.21±0.20(Predicted)
Storage Condition	under inert gas (nitrogen or Argon) at 2–8 °C
Refractive Index	1.604

2-chloro-5,6,7,8-tetrahydro-[1,6]naphthyridine - Introduction

2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine is an organic compound with the chemical formula C9H9ClN2. The following is a description of its nature, use, preparation and safety information:

Nature:
-Appearance: 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine is a white to beige solid.
-Solubility: It is soluble in some organic solvents (such as ethanol, dimethylformamide and dichloromethane).
-Melting point: Its melting point is 94-96°C.

Use:
-Chemical reagent: 2-choro-5, 6,7,8-tetrahydro-1,6-naphthyridine is a commonly used chemical reagent, often used in organic synthesis reactions.
-Drug intermediate: It can be used as an intermediate for the synthesis of certain drugs, used to prepare antibiotics, anti-cancer drugs and other drugs.

Method:
The preparation method of 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine is more complicated. A commonly used method of preparation is by reacting 2,3-dimethoxyquinazoline with Chloroacetyl Chloride under aluminum trichloride catalysis to give 2-chloroo-5, 6,7,8-tetrahydro-1,6-naphthyridine.

Safety Information:
- 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine is irritating and may cause irritation to the eyes, skin and respiratory tract.
-Wear appropriate protective gloves, glasses and protective clothing when using the compound.
-During storage and handling, follow proper laboratory safety procedures to ensure good ventilation.
-When handling this compound, avoid inhaling its dust or contact with skin.
-If you accidentally inhale, come into contact with, or ingest 2-Chloro-5,6,7,8-tetrahydro-1,6-naphthyridine, seek medical attention immediately.

Last Update：2024-04-09 02:00:44